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Assay Detail

CHEMBL1273206

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of mushroom tyrosinase after 20 mins by microplate reader analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Agaricus bisporus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosinase (CHEMBL3318)
Type SINGLE PROTEIN
Organism Agaricus bisporus

Publication

Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties.
Rho HS, Ahn SM, Yoo DS, Kim MK, Cho DH, Cho JY.
Bioorg Med Chem Lett (2010) 20 : 6569 -6571
PubMed 20934336 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.12 7.06

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1269426 1 7.06
CHEMBL1269399 1 7.01
CHEMBL1269400 1 6.72
CHEMBL1269398 1 5.83
CHEMBL1269350 1 5.71
CHEMBL1269349 1 5.58
CHEMBL1269401 1 5.58
CHEMBL1269425 1 4.34
CHEMBL1269471 1 4.31
CHEMBL1269472 1 4.16
CHEMBL1269428 1 4.13
CHEMBL1269470 1 4.12
CHEMBL1269427 1 4.10
CHEMBL1269469 1 4.10
CHEMBL287556 KOJIC ACID 1 4.06

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1269426 IC50 = 87.0 nM 7.06
CHEMBL1269399 IC50 = 97.0 nM 7.01
CHEMBL1269400 IC50 = 190.0 nM 6.72
CHEMBL1269398 IC50 = 1480.0 nM 5.83
CHEMBL1269350 IC50 = 1930.0 nM 5.71
CHEMBL1269349 IC50 = 2600.0 nM 5.58
CHEMBL1269401 IC50 = 2650.0 nM 5.58
CHEMBL1269425 IC50 = 46180.0 nM 4.34
CHEMBL1269471 IC50 = 49150.0 nM 4.31
CHEMBL1269472 IC50 = 69010.0 nM 4.16
CHEMBL1269428 IC50 = 73750.0 nM 4.13
CHEMBL1269470 IC50 = 76600.0 nM 4.12
CHEMBL1269427 IC50 = 79870.0 nM 4.10
CHEMBL1269469 IC50 = 79030.0 nM 4.10
CHEMBL287556 KOJIC ACID IC50 = 87380.0 nM 4.06