Assay Detail
Binding
CHEMBL1273286
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by patch clamp assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Factor Xa inhibitors: next-generation antithrombotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.70 | 6.70 |
| IC50 | 1 | 5.05 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473772 | — | — | 1 | 6.70 |
| CHEMBL512351 | BETRIXABAN | 4.0 | 1 | 5.05 |
| CHEMBL222012 | — | — | 1 | - |
| CHEMBL218315 | — | — | 1 | - |
| CHEMBL221231 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473772 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL512351 | BETRIXABAN | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL222012 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL218315 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL221231 | — | Ki | > | 10000.0 | nM | - |