Assay Detail
Binding
CHEMBL1273390
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His6x-tagged PRMT3-mediated arginine methylation expressed in Escherichia coli BL21 (DE3) using GAR R4 peptide and [14C]-SAM by scintillation counting
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 3 (CHEMBL5891) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and mechanistic study of a class of protein arginine methylation inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.15 | 5.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1092740 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1092740 | — | IC50 | = | 7100.0 | nM | 5.15 |