Assay Detail
Binding
CHEMBL1273398
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate by FRET assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus anthracis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 8.12 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1271420 | — | — | 1 | 10.30 |
| CHEMBL1269994 | — | — | 1 | 9.62 |
| CHEMBL1270304 | — | — | 1 | 9.52 |
| CHEMBL1270103 | — | — | 1 | 9.39 |
| CHEMBL1270210 | — | — | 1 | 9.36 |
| CHEMBL1270211 | — | — | 1 | 9.33 |
| CHEMBL1269887 | — | — | 1 | 9.16 |
| CHEMBL1269993 | — | — | 1 | 9.07 |
| CHEMBL1270102 | — | — | 1 | 8.96 |
| CHEMBL1270404 | — | — | 1 | 8.89 |
| CHEMBL1270305 | — | — | 1 | 8.85 |
| CHEMBL1270403 | — | — | 1 | 8.68 |
| CHEMBL1271419 | — | — | 1 | 8.51 |
| CHEMBL1271312 | — | — | 1 | 8.14 |
| CHEMBL1269054 | — | — | 1 | 8.09 |
| CHEMBL1269886 | — | — | 1 | 8.03 |
| CHEMBL1271003 | — | — | 1 | 7.96 |
| CHEMBL1270697 | — | — | 1 | 7.48 |
| CHEMBL1270905 | — | — | 1 | 7.38 |
| CHEMBL1270698 | — | — | 1 | 7.05 |
| CHEMBL1270496 | — | — | 1 | 7.02 |
| CHEMBL1270599 | — | — | 1 | 7.00 |
| CHEMBL1270802 | — | — | 1 | 6.94 |
| CHEMBL1270904 | — | — | 1 | 6.93 |
| CHEMBL1270497 | — | — | 1 | 6.91 |
| CHEMBL1271004 | — | — | 1 | 6.87 |
| CHEMBL1270801 | — | — | 1 | 6.82 |
| CHEMBL1270498 | — | — | 1 | 6.64 |
| CHEMBL1270598 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1271420 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL1269994 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL1270304 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL1270103 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL1270210 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL1270211 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL1269887 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL1269993 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL1270102 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1270404 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL1270305 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL1270403 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL1271419 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL1271312 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL1269054 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL1269886 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL1271003 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL1270697 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL1270905 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL1270698 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL1270496 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL1270599 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL1270802 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL1270904 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL1270497 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL1271004 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL1270801 | — | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL1270498 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL1270598 | — | Ki | = | 350.0 | nM | 6.46 |