Assay Detail
Binding
CHEMBL1273740
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His6x-tagged PRMT1-mediated arginine methylation expressed in Escherichia coli BL21 (DE3) using H4(1-11) and [14C]-SAM by scintillation counting
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 1 (CHEMBL5524) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and mechanistic study of a class of protein arginine methylation inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | - | - |
| Ki | 1 | 4.59 | 4.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL142304 | STILBAMIDINE | 2.0 | 1 | 4.59 |
| CHEMBL1092740 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL142304 | STILBAMIDINE | Ki | = | 25600.0 | nM | 4.59 |
| CHEMBL1092740 | — | IC50 | = | 176500.0 | nM | - |