Assay Detail
Binding
CHEMBL1274438
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Binding affinity to BCl2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.27 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 8.10 |
| CHEMBL192571 | — | — | 1 | 7.21 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL192571 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL51483 | GOSSYPOL | Ki | = | 320.0 | nM | 6.50 |