Assay Detail

CHEMBL1274516

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of human PP2A expressed in Escherichia coli BL21

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

The antiplasmodial activity of norcantharidin analogs.

Bajsa J, McCluskey A, Gordon CP, Stewart SG, Hill TA, Sahu R, Duke SO, Tekwani BL.
Bioorg Med Chem Lett (2010) 20 : 6688 -6695
PubMed 20888768 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	6.72	7.05

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL428650	ENDOTHALL	—	1	7.05
CHEMBL48449	CANTHARIDIN	4.0	1	6.70
CHEMBL8327	DEMETHYL-CANTHARIDIN	—	1	6.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL428650	ENDOTHALL	IC50	=	90.0	nM	7.05
CHEMBL48449	CANTHARIDIN	IC50	=	200.0	nM	6.70
CHEMBL8327	DEMETHYL-CANTHARIDIN	IC50	=	400.0	nM	6.40