Assay Detail

CHEMBL1283372

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antimalarial activity against Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine uptake

ChEMBL ↗

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Target

Plasmodium falciparum (CHEMBL364) ↗

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Primary target Plasmodium falciparum

CHEMBL364

Anchored from Assay target.

Protein identity Plasmodium falciparum

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Plasmodium falciparum
Confidence	1 — Organism
Curated By	Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗

Type	ORGANISM
Organism	Plasmodium falciparum

Publication

Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum.

Chavchich M, Gerena L, Peters J, Chen N, Cheng Q, Kyle DE.
Antimicrob Agents Chemother (2010) 54 : 2455 -2464
PubMed 20350946 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.36	8.36
IC90	1	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1208264	ARTELINIC ACID	—	2	8.36

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1208264	ARTELINIC ACID	IC50	=	4.37	nM	8.36
CHEMBL1208264	ARTELINIC ACID	IC90	=	7.45	nM	-