Assay Detail
Binding
CHEMBL1285218
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SCD1 in mouse microsome assessed as reduction in conversion of [14C]stearic acid to [14C]oleic acid after 30 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4'-piperidine] analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 9.10 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276595 | — | — | 1 | 10.40 |
| CHEMBL593108 | — | — | 1 | 10.22 |
| CHEMBL1276653 | — | — | 1 | 9.70 |
| CHEMBL1276623 | — | — | 1 | 9.30 |
| CHEMBL1276654 | — | — | 1 | 8.70 |
| CHEMBL1276685 | — | — | 1 | 8.70 |
| CHEMBL1276686 | — | — | 1 | 8.52 |
| CHEMBL1276720 | — | — | 1 | 8.40 |
| CHEMBL1276721 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276595 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL593108 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL1276653 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1276623 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1276654 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1276685 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1276686 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1276720 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1276721 | — | IC50 | = | 10.0 | nM | 8.00 |