Assay Detail
Binding
CHEMBL1285503
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Competitive inhibition of mushroom tyrosinase after 15 mins by Lineweaver-Burke plot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.80 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1275999 | GAMMA-THUJAPLICIN | — | 1 | 7.70 |
| CHEMBL48310 | HINOKITIOL | — | 1 | 7.22 |
| CHEMBL1275969 | ALPHA-THUJAPLICIN | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1275999 | GAMMA-THUJAPLICIN | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL48310 | HINOKITIOL | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL1275969 | ALPHA-THUJAPLICIN | Ki | = | 3300.0 | nM | 5.48 |