Assay Detail
Binding
CHEMBL1285768
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Inhibition of Plasmodium falciparum recombinant falcipain-2
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.38 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1277432 | — | — | 1 | 8.85 |
| CHEMBL1277524 | — | — | 1 | 7.79 |
| CHEMBL3084785 | — | — | 1 | 6.37 |
| CHEMBL1277712 | — | — | 1 | 6.36 |
| CHEMBL3084790 | — | — | 1 | 6.29 |
| CHEMBL3084787 | — | — | 1 | 5.92 |
| CHEMBL1277711 | — | — | 1 | 5.71 |
| CHEMBL1277618 | — | — | 1 | 5.71 |
| CHEMBL327290 | — | — | 1 | 5.69 |
| CHEMBL100095 | — | — | 1 | 5.15 |
| CHEMBL3084786 | — | — | 1 | - |
| CHEMBL3084788 | — | — | 1 | - |
| CHEMBL3084789 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1277432 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1277524 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL3084785 | — | IC50 | = | 425.3 | nM | 6.37 |
| CHEMBL1277712 | — | IC50 | = | 437.7 | nM | 6.36 |
| CHEMBL3084790 | — | IC50 | = | 510.23 | nM | 6.29 |
| CHEMBL3084787 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1277711 | — | IC50 | = | 1961.0 | nM | 5.71 |
| CHEMBL1277618 | — | IC50 | = | 1966.0 | nM | 5.71 |
| CHEMBL327290 | — | IC50 | = | 2048.5 | nM | 5.69 |
| CHEMBL100095 | — | IC50 | = | 7149.5 | nM | 5.15 |
| CHEMBL3084786 | — | IC50 | < | 11500.0 | nM | - |
| CHEMBL3084788 | — | IC50 | < | 8668.0 | nM | - |
| CHEMBL3084789 | — | IC50 | < | 8583.0 | nM | - |