Assay Detail
Binding
CHEMBL1285769
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Inhibition of Plasmodium falciparum recombinant falcipain-3
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.79 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1277432 | — | — | 1 | 6.70 |
| CHEMBL1277524 | — | — | 1 | 6.67 |
| CHEMBL1277712 | — | — | 1 | 6.65 |
| CHEMBL3084790 | — | — | 1 | 6.48 |
| CHEMBL327290 | — | — | 1 | 6.07 |
| CHEMBL3084785 | — | — | 1 | 6.02 |
| CHEMBL100095 | — | — | 1 | 5.25 |
| CHEMBL1277618 | — | — | 1 | 5.07 |
| CHEMBL1277711 | — | — | 1 | 4.67 |
| CHEMBL3084787 | — | — | 1 | 4.36 |
| CHEMBL3084786 | — | — | 1 | - |
| CHEMBL3084788 | — | — | 1 | - |
| CHEMBL3084789 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1277432 | — | IC50 | = | 198.9 | nM | 6.70 |
| CHEMBL1277524 | — | IC50 | = | 214.6 | nM | 6.67 |
| CHEMBL1277712 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL3084790 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL327290 | — | IC50 | = | 853.0 | nM | 6.07 |
| CHEMBL3084785 | — | IC50 | = | 947.0 | nM | 6.02 |
| CHEMBL100095 | — | IC50 | = | 5597.0 | nM | 5.25 |
| CHEMBL1277618 | — | IC50 | = | 8613.0 | nM | 5.07 |
| CHEMBL1277711 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL3084787 | — | IC50 | = | 44155.0 | nM | 4.36 |
| CHEMBL3084786 | — | IC50 | < | 19780.0 | nM | - |
| CHEMBL3084788 | — | IC50 | < | 24215.0 | nM | - |
| CHEMBL3084789 | — | IC50 | > | 25000.0 | nM | - |