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Assay Detail

CHEMBL1285900

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Trypanosoma cruzi cruzaine pre-incubated for 10 mins
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Trypanosoma cruzi
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cruzipain (CHEMBL3563)
Type SINGLE PROTEIN
Organism Trypanosoma cruzi

Publication

Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents.
Hernandes MZ, Rabello MM, Leite AC, Cardoso MV, Moreira DR, Brondani DJ, Simone CA, Reis LC, Souza MA, Pereira VR, Ferreira RS, McKerrow JH.
Bioorg Med Chem (2010) 18 : 7826 -7835
PubMed 20961766 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.57 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL313679 1 7.40
CHEMBL1275672 1 7.22
CHEMBL90512 1 7.00
CHEMBL1276253 1 6.70
CHEMBL1276198 1 6.40
CHEMBL1276301 1 4.69
CHEMBL1276254 1 -
CHEMBL1276231 1 -
CHEMBL1277144 1 -
CHEMBL1277057 1 -
CHEMBL1277145 1 -
CHEMBL1276300 1 -
CHEMBL1276197 1 -
CHEMBL1276230 1 -
CHEMBL1276229 1 -
CHEMBL1276228 1 -
CHEMBL1276302 1 -
CHEMBL1276255 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL313679 IC50 = 40.0 nM 7.40
CHEMBL1275672 IC50 = 60.0 nM 7.22
CHEMBL90512 IC50 = 100.0 nM 7.00
CHEMBL1276253 IC50 = 200.0 nM 6.70
CHEMBL1276198 IC50 = 400.0 nM 6.40
CHEMBL1276301 IC50 = 20400.0 nM 4.69
CHEMBL1276254 IC50 - -
CHEMBL1276231 IC50 - -
CHEMBL1277144 IC50 - -
CHEMBL1277057 IC50 - -
CHEMBL1277145 IC50 - -
CHEMBL1276300 IC50 - -
CHEMBL1276197 IC50 - -
CHEMBL1276230 IC50 - -
CHEMBL1276229 IC50 - -
CHEMBL1276228 IC50 - -
CHEMBL1276302 IC50 - -
CHEMBL1276255 IC50 - -