Assay Detail
Binding
CHEMBL1286072
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium tuberculosis zinc dependent class 2 Fba
8
Total Activities
7
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Fructose-bisphosphate aldolase (CHEMBL1287620) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Rational design, synthesis, and evaluation of new selective inhibitors of microbial class II (zinc dependent) fructose bis-phosphate aldolases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Km | 4 | - | - |
| Ki | 3 | 6.45 | 7.89 |
| IC50 | 1 | 8.49 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1236228 | — | — | 2 | 8.49 |
| CHEMBL1235276 | — | — | 1 | 7.89 |
| CHEMBL1276292 | — | — | 1 | 6.77 |
| CHEMBL1235112 | — | — | 1 | 4.68 |
| CHEMBL1236227 | — | — | 1 | - |
| CHEMBL1278086 | — | — | 1 | - |
| CHEMBL1278173 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1236228 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL1235276 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL1276292 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL1235112 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL1236228 | — | Km | = | 1.0 | nM | - |
| CHEMBL1236227 | — | Km | = | 185.0 | nM | - |
| CHEMBL1278086 | — | Km | = | 120.0 | nM | - |
| CHEMBL1278173 | — | Km | = | 310.0 | nM | - |