Assay Detail
Functional
CHEMBL1286348
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Cytotoxicity against human LAMA-84 cells after 48 hrs by Alamar blue assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LAMA-84 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Sterols as anticancer agents: synthesis of ring-B oxygenated steroids, cytotoxic profile, and comprehensive SAR analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.30 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.13 |
| CHEMBL497834 | — | — | 1 | 5.37 |
| CHEMBL1277284 | — | — | 1 | 5.33 |
| CHEMBL1278089 | CHOLESTAN-3beta,5alpha,6beta-TRIOL | — | 1 | 5.30 |
| CHEMBL1277997 | — | — | 1 | 5.25 |
| CHEMBL1277103 | — | — | 1 | 5.15 |
| CHEMBL1276293 | — | — | 1 | 5.12 |
| CHEMBL455367 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL497834 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1277284 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1278089 | CHOLESTAN-3beta,5alpha,6beta-TRIOL | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1277997 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1277103 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL1276293 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL455367 | — | IC50 | = | 17700.0 | nM | 4.75 |