Assay Detail
Binding
CHEMBL1286651
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Inhibition of Fischer-344 rat kidney AK1A1
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member A1 (CHEMBL3871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.95 | 6.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1277476 | — | — | 1 | 6.49 |
| CHEMBL1277203 | — | — | 1 | 5.16 |
| CHEMBL1277477 | — | — | 1 | 5.01 |
| CHEMBL507525 | — | — | 1 | 4.99 |
| CHEMBL1277386 | — | — | 1 | 4.92 |
| CHEMBL1277297 | — | — | 1 | 4.91 |
| CHEMBL1277387 | — | — | 1 | 4.81 |
| CHEMBL458568 | — | — | 1 | 4.71 |
| CHEMBL458588 | — | — | 1 | 4.62 |
| CHEMBL1277298 | — | — | 1 | 4.59 |
| CHEMBL109 | VALPROIC ACID | 4.0 | 1 | 4.25 |
| CHEMBL457486 | — | — | 1 | - |
| CHEMBL1277113 | — | — | 1 | - |
| CHEMBL1277202 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1277476 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL1277203 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL1277477 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL507525 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL1277386 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL1277297 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL1277387 | — | IC50 | = | 15420.0 | nM | 4.81 |
| CHEMBL458568 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL458588 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL1277298 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL109 | VALPROIC ACID | IC50 | = | 56100.0 | nM | 4.25 |
| CHEMBL457486 | — | IC50 | = | 132900.0 | nM | - |
| CHEMBL1277113 | — | IC50 | = | 105200.0 | nM | - |
| CHEMBL1277202 | — | IC50 | = | 280700.0 | nM | - |