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Assay Detail

CHEMBL1286658

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antioxidant activity assessed as DPPH radical scavenging activity after 270 mins by least-square analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 3 — Cell-line / Tissue
Curated By Autocuration

Publication

A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activity.
Alexiou P, Demopoulos VJ.
J Med Chem (2010) 53 : 7756 -7766
PubMed 20936791 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.29 4.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL153 TROLOX 1 4.43
CHEMBL1277113 1 4.35
CHEMBL507525 1 4.35
CHEMBL458588 1 4.34
CHEMBL458568 1 4.31
CHEMBL1277202 1 4.31
CHEMBL1277203 1 4.30
CHEMBL1277298 1 4.29
CHEMBL457486 1 4.26
CHEMBL1277297 1 4.25
CHEMBL1277386 1 4.21
CHEMBL1277387 1 4.21
CHEMBL1277476 1 4.21
CHEMBL1277477 1 4.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL153 TROLOX IC50 = 37000.0 nM 4.43
CHEMBL1277113 IC50 = 45100.0 nM 4.35
CHEMBL507525 IC50 = 44700.0 nM 4.35
CHEMBL458588 IC50 = 45200.0 nM 4.34
CHEMBL458568 IC50 = 49000.0 nM 4.31
CHEMBL1277202 IC50 = 48600.0 nM 4.31
CHEMBL1277203 IC50 = 49700.0 nM 4.30
CHEMBL1277298 IC50 = 51600.0 nM 4.29
CHEMBL457486 IC50 = 54800.0 nM 4.26
CHEMBL1277297 IC50 = 56900.0 nM 4.25
CHEMBL1277386 IC50 = 60900.0 nM 4.21
CHEMBL1277387 IC50 = 61500.0 nM 4.21
CHEMBL1277476 IC50 = 61900.0 nM 4.21
CHEMBL1277477 IC50 = 63200.0 nM 4.20