Assay Detail
Functional
CHEMBL1286930
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Antiproliferative activity against human SKOV3 cells expressing MDR1-6/6 by sulforhodamine B assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.62 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1206232 | FOSBRETABULIN | 3.0 | 1 | 8.18 |
| CHEMBL1277064 | — | — | 1 | 7.35 |
| CHEMBL1275943 | — | — | 1 | 6.36 |
| CHEMBL299613 | 2-METHOXYESTRADIOL | 2.0 | 1 | 5.64 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1206232 | FOSBRETABULIN | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL1277064 | — | IC50 | = | 44.4 | nM | 7.35 |
| CHEMBL1275943 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL299613 | 2-METHOXYESTRADIOL | IC50 | = | 2268.0 | nM | 5.64 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2600.0 | nM | 5.58 |