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Assay Detail

CHEMBL1287450

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Binding
Binding affinity to human adenosine A3 receptor
15
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Adenosine receptor A3 (CHEMBL256)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Molecular modeling study on potent and selective adenosine A(3) receptor agonists.
Dal Ben D, Buccioni M, Lambertucci C, Marucci G, Thomas A, Volpini R, Cristalli G.
Bioorg Med Chem (2010) 18 : 7923 -7930
PubMed 20943397 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 8.66 9.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1277130 1 9.48
CHEMBL575027 1 9.40
CHEMBL573269 1 9.37
CHEMBL574602 1 9.36
CHEMBL223514 1 8.96
CHEMBL221206 1 8.72
CHEMBL427077 1 8.72
CHEMBL223625 1 8.60
CHEMBL574597 2 8.47
CHEMBL573030 1 8.40
CHEMBL1277040 2 8.14
CHEMBL375190 2 7.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1277130 Ki = 0.3311 nM 9.48
CHEMBL575027 Ki = 0.3981 nM 9.40
CHEMBL573269 Ki = 0.4266 nM 9.37
CHEMBL574602 Ki = 0.4365 nM 9.36
CHEMBL223514 Ki = 1.096 nM 8.96
CHEMBL221206 Ki = 1.905 nM 8.72
CHEMBL427077 Ki = 1.905 nM 8.72
CHEMBL223625 Ki = 2.512 nM 8.60
CHEMBL574597 Ki = 3.4 nM 8.47
CHEMBL574597 Ki = 3.388 nM 8.47
CHEMBL573030 Ki = 3.981 nM 8.40
CHEMBL1277040 Ki = 7.3 nM 8.14
CHEMBL1277040 Ki = 7.244 nM 8.14
CHEMBL375190 Ki = 16.0 nM 7.80
CHEMBL375190 Ki = 15.85 nM 7.80