Assay Detail
Binding
CHEMBL1287512
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Inhibition of Plasmodium falciparum PNP expressed in Escherichia coli BL21(DE3) cells by spectrophotometry
20
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Purine nucleoside phosphorylase (CHEMBL5648) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.39 | 9.07 |
| IC50 | 10 | 4.38 | 4.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218291 | FORODESINE | 4.0 | 1 | 9.07 |
| CHEMBL1277898 | — | — | 2 | 8.96 |
| CHEMBL1275659 | — | — | 1 | 8.57 |
| CHEMBL1275720 | — | — | 2 | 5.22 |
| CHEMBL1275699 | — | — | 2 | 4.57 |
| CHEMBL1275700 | — | — | 2 | 4.23 |
| CHEMBL1275721 | — | — | 2 | 4.12 |
| CHEMBL37519 | — | — | 1 | - |
| CHEMBL1275661 | — | — | 1 | - |
| CHEMBL1275701 | — | — | 2 | - |
| CHEMBL1275702 | — | — | 2 | - |
| CHEMBL1275719 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218291 | FORODESINE | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL1277898 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1275659 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL1275720 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL1275699 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL1275720 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL1275700 | — | Ki | = | 59000.0 | nM | 4.23 |
| CHEMBL1275721 | — | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL37519 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1277898 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1275661 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1275701 | — | Ki | = | 136000.0 | nM | - |
| CHEMBL1275702 | — | Ki | = | 105000.0 | nM | - |
| CHEMBL1275719 | — | Ki | = | 113000.0 | nM | - |
| CHEMBL1275699 | — | IC50 | = | 141000.0 | nM | - |
| CHEMBL1275700 | — | IC50 | = | 230000.0 | nM | - |
| CHEMBL1275701 | — | IC50 | = | 712000.0 | nM | - |
| CHEMBL1275702 | — | IC50 | = | 524000.0 | nM | - |
| CHEMBL1275719 | — | IC50 | = | 592000.0 | nM | - |
| CHEMBL1275721 | — | IC50 | = | 366000.0 | nM | - |