Assay Detail
Binding
CHEMBL1292094
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Inhibition of human cathepsin B by fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.18 | 5.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1289645 | — | — | 1 | 5.49 |
| CHEMBL1289305 | — | — | 1 | 5.24 |
| CHEMBL1289644 | — | — | 1 | 4.82 |
| CHEMBL1289856 | — | — | 1 | - |
| CHEMBL1289857 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1289645 | — | IC50 | = | 3236.0 | nM | 5.49 |
| CHEMBL1289305 | — | IC50 | = | 5754.0 | nM | 5.24 |
| CHEMBL1289644 | — | IC50 | = | 15136.0 | nM | 4.82 |
| CHEMBL1289856 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1289857 | — | IC50 | > | 10000.0 | nM | - |