Assay Detail
Binding
CHEMBL1293060
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human recombinant TRPV1
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.04 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294199 | CAPSAICIN | 4.0 | 1 | 8.22 |
| CHEMBL17976 | RESINIFERATOXIN | 3.0 | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294199 | CAPSAICIN | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL17976 | RESINIFERATOXIN | Ki | = | 14.0 | nM | 7.85 |