Assay Detail
Binding
CHEMBL1293140
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Inhibition of Plasmodium falciparum 3D7 HDAC1 in infected-human erythrocytes assessed as histone H4 hyperacetylation after 1.5 hrs by SDS-PAGE analysis
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum 3D7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.09 | 7.11 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221655 | — | — | 2 | 7.11 |
| CHEMBL220692 | — | — | 2 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221655 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL220692 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL221655 | — | Inhibition | - | % | - | |
| CHEMBL220692 | — | Inhibition | - | % | - |