Assay Detail
Functional
CHEMBL1293145
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
5-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-2(1H)-quinolinones and 3,4-dihydro-2(1H)-quinolinones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors. Part 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.62 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1289048 | — | — | 1 | 7.20 |
| CHEMBL1290596 | — | — | 1 | 6.70 |
| CHEMBL1289164 | — | — | 1 | 6.50 |
| CHEMBL1290597 | — | — | 1 | 6.40 |
| CHEMBL1289047 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1289048 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL1290596 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL1289164 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL1290597 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL1289047 | — | EC50 | = | 501.19 | nM | 6.30 |