Assay Detail
Functional
CHEMBL1613864
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Luminescent HTS for small molecule inhibitors of MT1-MMP transcription. (Class of assay: confirmatory) [Related pubchem assays: 620, 773 ]
270
Total Activities
270
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Category | confirmatory |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 270 | 5.48 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1440954 | — | — | 1 | 6.96 |
| CHEMBL1370087 | — | — | 1 | 6.96 |
| CHEMBL1576870 | — | — | 1 | 6.89 |
| CHEMBL1482541 | — | — | 1 | 6.85 |
| CHEMBL3190812 | — | — | 1 | 6.75 |
| CHEMBL3190131 | — | — | 1 | 6.72 |
| CHEMBL1379970 | — | — | 1 | 6.70 |
| CHEMBL1427279 | — | — | 1 | 6.70 |
| CHEMBL1307919 | — | — | 1 | 6.68 |
| CHEMBL1537098 | — | — | 1 | 6.64 |
| CHEMBL1303835 | — | — | 1 | 6.64 |
| CHEMBL1543238 | — | — | 1 | 6.64 |
| CHEMBL1572157 | — | — | 1 | 6.60 |
| CHEMBL1510646 | — | — | 1 | 6.57 |
| CHEMBL1480522 | — | — | 1 | 6.55 |
| CHEMBL482116 | — | — | 1 | 6.52 |
| CHEMBL1521023 | — | — | 1 | 6.51 |
| CHEMBL1518672 | — | — | 1 | 6.46 |
| CHEMBL1393129 | — | — | 1 | 6.40 |
| CHEMBL1320514 | — | — | 1 | 6.38 |
| CHEMBL1612106 | — | — | 1 | 6.27 |
| CHEMBL1571615 | — | — | 1 | 6.26 |
| CHEMBL1491705 | — | — | 1 | 6.24 |
| CHEMBL3196469 | — | — | 1 | 6.24 |
| CHEMBL1496640 | — | — | 1 | 6.24 |
| CHEMBL1495417 | — | — | 1 | 6.23 |
| CHEMBL1327298 | — | — | 1 | 6.23 |
| CHEMBL1331514 | — | — | 1 | 6.22 |
| CHEMBL1459767 | — | — | 1 | 6.21 |
| CHEMBL1579878 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1370087 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1440954 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1576870 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1482541 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3190812 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3190131 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1427279 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1379970 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1307919 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1543238 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1303835 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1537098 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1572157 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1510646 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1480522 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL482116 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1521023 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1518672 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1393129 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1320514 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1612106 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1571615 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1491705 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3196469 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL1496640 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL1495417 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1327298 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1331514 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1579878 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL1459767 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL1502133 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL1416853 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL1487967 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL1369231 | — | EC50 | = | 670.0 | nM | 6.17 |
| CHEMBL1386804 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1577938 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL1493429 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3191594 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL1320414 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL1450119 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL1993627 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL475627 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL1600459 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL260342 | — | EC50 | = | 970.0 | nM | 6.01 |
| CHEMBL1570371 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1427801 | — | EC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL1329446 | — | EC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL374632 | — | EC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL1363955 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL1323978 | — | EC50 | = | 1120.0 | nM | 5.95 |