Assay Detail
Functional
CHEMBL1613882
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Late stage results from the probe development effort to identify inhibitors of (NADPH oxidase 1) NOX1: Xanthine Oxidase. (Class of assay: confirmatory) [Related pubchem assays: 2752 (Primary screen (NOX1 inhibitors, synthesized analogs set 2)), 2532 (Dose response (NOX1 inhibitors, HEK/293 cells)), 2664 (Primary screen (NOX1 inhibitors, synthesized analogs)), 1792 (Primary Screen (NOX1)), 2538 (Dose response screen (NOX1 inhibitors)), 1796 (Summary AID (NOX1)), 2545 (Confirmation screen (NOX1 inhibitors, HEK/293 cells)), 2539 (Counterscreen (NOX2, NOX3, NOX4 inhibitors)), 2541 (Confirmation screen (NOX1 inhibitors)), 1823 (Counterscreen (luminal))]
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Category | confirmatory |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.12 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1473456 | — | — | 1 | 5.70 |
| CHEMBL1489079 | — | — | 1 | 5.46 |
| CHEMBL1400134 | — | — | 1 | 4.96 |
| CHEMBL1434771 | — | — | 1 | 4.96 |
| CHEMBL441558 | — | — | 1 | 4.95 |
| CHEMBL541018 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1473456 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1489079 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1400134 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL1434771 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL441558 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL541018 | — | IC50 | = | 20700.0 | nM | 4.68 |