Assay Detail
Binding
CHEMBL1614321
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. (Class of assay: confirmatory) [Related pubchem assays: 2090 (Summary AID.), 2057 (Screening assay (MCL1 inhibitors).), 2168 (Screening assay (MCL1 inhibitors).)]
128
Total Activities
128
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | myeloid |
| Category | confirmatory |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 128 | 4.97 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL458328 | — | — | 1 | 6.36 |
| CHEMBL1468800 | — | — | 1 | 5.76 |
| CHEMBL1981200 | — | — | 1 | 5.70 |
| CHEMBL1580684 | — | — | 1 | 5.70 |
| CHEMBL3197557 | — | — | 1 | 5.68 |
| CHEMBL3192179 | — | — | 1 | 5.63 |
| CHEMBL1410381 | — | — | 1 | 5.57 |
| CHEMBL1449836 | — | — | 1 | 5.54 |
| CHEMBL1968789 | — | — | 1 | 5.53 |
| CHEMBL1592276 | — | — | 1 | 5.46 |
| CHEMBL1435948 | — | — | 1 | 5.45 |
| CHEMBL578585 | — | — | 1 | 5.39 |
| CHEMBL1373095 | — | — | 1 | 5.37 |
| CHEMBL1360150 | — | — | 1 | 5.36 |
| CHEMBL1387693 | — | — | 1 | 5.31 |
| CHEMBL119171 | — | — | 1 | 5.31 |
| CHEMBL1538505 | — | — | 1 | 5.29 |
| CHEMBL1449253 | — | — | 1 | 5.29 |
| CHEMBL165064 | ISOKAEMPFERIDE | — | 1 | 5.27 |
| CHEMBL469424 | ASTERRIC ACID | — | 1 | 5.26 |
| CHEMBL1311053 | — | — | 1 | 5.22 |
| CHEMBL1543965 | — | — | 1 | 5.21 |
| CHEMBL1365170 | — | — | 1 | 5.20 |
| CHEMBL1401406 | — | — | 1 | 5.20 |
| CHEMBL1417070 | — | — | 1 | 5.18 |
| CHEMBL1518374 | — | — | 1 | 5.17 |
| CHEMBL3189416 | — | — | 1 | 5.17 |
| CHEMBL1319129 | — | — | 1 | 5.14 |
| CHEMBL1706577 | — | — | 1 | 5.14 |
| CHEMBL1415426 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL458328 | — | IC50 | = | 441.49 | nM | 6.36 |
| CHEMBL1468800 | — | IC50 | = | 1742.0 | nM | 5.76 |
| CHEMBL1981200 | — | IC50 | = | 2016.0 | nM | 5.70 |
| CHEMBL1580684 | — | IC50 | = | 1996.0 | nM | 5.70 |
| CHEMBL3197557 | — | IC50 | = | 2067.0 | nM | 5.68 |
| CHEMBL3192179 | — | IC50 | = | 2333.0 | nM | 5.63 |
| CHEMBL1410381 | — | IC50 | = | 2697.0 | nM | 5.57 |
| CHEMBL1449836 | — | IC50 | = | 2916.0 | nM | 5.54 |
| CHEMBL1968789 | — | IC50 | = | 2939.0 | nM | 5.53 |
| CHEMBL1592276 | — | IC50 | = | 3455.0 | nM | 5.46 |
| CHEMBL1435948 | — | IC50 | = | 3515.0 | nM | 5.45 |
| CHEMBL578585 | — | IC50 | = | 4051.0 | nM | 5.39 |
| CHEMBL1373095 | — | IC50 | = | 4261.0 | nM | 5.37 |
| CHEMBL1360150 | — | IC50 | = | 4408.0 | nM | 5.36 |
| CHEMBL119171 | — | IC50 | = | 4940.0 | nM | 5.31 |
| CHEMBL1387693 | — | IC50 | = | 4935.0 | nM | 5.31 |
| CHEMBL1449253 | — | IC50 | = | 5139.0 | nM | 5.29 |
| CHEMBL1538505 | — | IC50 | = | 5161.0 | nM | 5.29 |
| CHEMBL165064 | ISOKAEMPFERIDE | IC50 | = | 5405.0 | nM | 5.27 |
| CHEMBL469424 | ASTERRIC ACID | IC50 | = | 5478.0 | nM | 5.26 |
| CHEMBL1311053 | — | IC50 | = | 6080.0 | nM | 5.22 |
| CHEMBL1543965 | — | IC50 | = | 6158.0 | nM | 5.21 |
| CHEMBL1365170 | — | IC50 | = | 6272.0 | nM | 5.20 |
| CHEMBL1401406 | — | IC50 | = | 6338.0 | nM | 5.20 |
| CHEMBL1417070 | — | IC50 | = | 6538.0 | nM | 5.18 |
| CHEMBL3189416 | — | IC50 | = | 6835.0 | nM | 5.17 |
| CHEMBL1518374 | — | IC50 | = | 6802.0 | nM | 5.17 |
| CHEMBL1319129 | — | IC50 | = | 7310.0 | nM | 5.14 |
| CHEMBL1706577 | — | IC50 | = | 7186.0 | nM | 5.14 |
| CHEMBL1415426 | — | IC50 | = | 7395.0 | nM | 5.13 |
| CHEMBL1315784 | — | IC50 | = | 8305.0 | nM | 5.08 |
| CHEMBL571296 | — | IC50 | = | 8582.0 | nM | 5.07 |
| CHEMBL1453409 | — | IC50 | = | 8626.0 | nM | 5.06 |
| CHEMBL1454531 | — | IC50 | = | 8772.0 | nM | 5.06 |
| CHEMBL1446458 | — | IC50 | = | 8739.0 | nM | 5.06 |
| CHEMBL1451039 | — | IC50 | = | 8627.0 | nM | 5.06 |
| CHEMBL1439414 | — | IC50 | = | 8640.0 | nM | 5.06 |
| CHEMBL1966952 | — | IC50 | = | 9130.0 | nM | 5.04 |
| CHEMBL1576140 | — | IC50 | = | 9373.0 | nM | 5.03 |
| CHEMBL1385808 | — | IC50 | = | 9385.0 | nM | 5.03 |
| CHEMBL1397916 | — | IC50 | = | 9630.0 | nM | 5.02 |
| CHEMBL1359782 | — | IC50 | = | 9601.0 | nM | 5.02 |
| CHEMBL1543134 | — | IC50 | = | 9697.0 | nM | 5.01 |
| CHEMBL1964442 | — | IC50 | = | 10016.0 | nM | 5.00 |
| CHEMBL1978364 | — | IC50 | = | 10789.0 | nM | 4.97 |
| CHEMBL1512376 | — | IC50 | = | 10948.0 | nM | 4.96 |
| CHEMBL1467730 | — | IC50 | = | 11079.0 | nM | 4.96 |
| CHEMBL1991426 | — | IC50 | = | 11280.0 | nM | 4.95 |
| CHEMBL1538897 | — | IC50 | = | 11425.0 | nM | 4.94 |
| CHEMBL1312353 | — | IC50 | = | 11700.0 | nM | 4.93 |