Assay Detail
Functional
CHEMBL1614324
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Late stage results from the probe development effort to identify inhibitors of (NADPH oxidase 1) NOX1: Xanthine Oxidase Set 2. (Class of assay: confirmatory) [Related pubchem assays: 434953 (Psychoactive Drug Screening Program secondary screen (NOX1 inhibitors)), 2752 (Primary screen (NOX1 inhibitors, synthesized analogs set 2)), 2532 (Dose response (NOX1 inhibitors, HEK/293 cells)), 2819 (Primary screen (NOX1 inhibitors, purchased analogs set 2)), 2664 (Primary screen (NOX1 inhibitors, synthesized analogs)), 1792 (Primary Screen (NOX1 inhibitors)), 434997 (Dose response (NOX1 inhibitors, cherry picks 2)), 2556 (Counterscreen (Xanthine oxidase inhibitors)), 2538 (Dose response screen (NOX1 inhibitors)), 2808 (Primary screen (NOX1 inhibitors, purchased analogs)), 1796 (Summary AID (NOX1 inhibitors)), 434974 (Psychoactive Drug Screening Program primary screen (NOX1 inhibitors)), 2773 (Primary screen (NOX1 inhibitors, synthesized analogs set 3)), 2545 (Confirmation screen (NOX1 inhibitors, HEK/293 cells)), 2539 (Counterscreen (NOX2, NOX3, NOX4 inhibitors)), 2541 (Confirmation screen (NOX1 inhibitors)), 1823 (Counterscreen (luminal))]
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Category | confirmatory |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.03 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441558 | — | — | 1 | 8.00 |
| CHEMBL1550870 | — | — | 1 | 6.30 |
| CHEMBL587104 | — | — | 1 | 6.05 |
| CHEMBL1394104 | — | — | 1 | 5.92 |
| CHEMBL1473456 | — | — | 1 | 5.89 |
| CHEMBL1434771 | — | — | 1 | 5.48 |
| CHEMBL541018 | — | — | 1 | 5.30 |
| CHEMBL407734 | — | — | 1 | 5.26 |
| CHEMBL1517979 | — | — | 1 | - |
| CHEMBL1315444 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441558 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1550870 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL587104 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1394104 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1473456 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1434771 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL541018 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL407734 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1517979 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1315444 | — | IC50 | > | 50000.0 | nM | - |