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Assay Detail

CHEMBL1614529

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1022 (Primary screen preceding this dose-response assay.)]
ChEMBL ↗
1106
Total Activities
1105
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Category confirmatory
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1106 5.43 6.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1610008 — — 1 6.38
CHEMBL3197153 — — 1 6.37
CHEMBL3210158 — — 1 6.36
CHEMBL1366030 — — 1 6.35
CHEMBL1330018 — — 1 6.34
CHEMBL1540071 — — 1 6.33
CHEMBL1604260 — — 1 6.25
CHEMBL1411862 — — 1 6.24
CHEMBL1413735 — — 1 6.20
CHEMBL1530511 — — 1 6.14
CHEMBL3193785 — — 1 6.14
CHEMBL1582121 — — 1 6.14
CHEMBL1493936 — — 1 6.13
CHEMBL1458891 — — 1 6.12
CHEMBL1351799 — — 1 6.12
CHEMBL1468811 — — 1 6.11
CHEMBL1586658 — — 1 6.10
CHEMBL1408047 — — 1 6.10
CHEMBL1501132 — — 1 6.08
CHEMBL1986081 — — 1 6.08
CHEMBL1524128 — — 1 6.07
CHEMBL1374241 — — 1 6.07
CHEMBL1565212 — — 1 6.05
CHEMBL1701224 — — 1 6.05
CHEMBL1607313 — — 1 6.04
CHEMBL1509707 — — 1 6.04
CHEMBL1567402 — — 1 6.03
CHEMBL1351018 — — 1 6.03
CHEMBL1407756 — — 1 6.02
CHEMBL1334633 — — 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1610008 — IC50 = 416.66 nM 6.38
CHEMBL3197153 — IC50 = 431.45 nM 6.37
CHEMBL3210158 — IC50 = 433.42 nM 6.36
CHEMBL1366030 — IC50 = 449.41 nM 6.35
CHEMBL1330018 — IC50 = 455.14 nM 6.34
CHEMBL1540071 — IC50 = 473.03 nM 6.33
CHEMBL1604260 — IC50 = 556.52 nM 6.25
CHEMBL1411862 — IC50 = 578.78 nM 6.24
CHEMBL1413735 — IC50 = 627.86 nM 6.20
CHEMBL1582121 — IC50 = 729.9 nM 6.14
CHEMBL1530511 — IC50 = 718.91 nM 6.14
CHEMBL3193785 — IC50 = 730.16 nM 6.14
CHEMBL1493936 — IC50 = 745.12 nM 6.13
CHEMBL1458891 — IC50 = 767.07 nM 6.12
CHEMBL1351799 — IC50 = 751.61 nM 6.12
CHEMBL1468811 — IC50 = 785.89 nM 6.11
CHEMBL1408047 — IC50 = 799.37 nM 6.10
CHEMBL1586658 — IC50 = 800.42 nM 6.10
CHEMBL1501132 — IC50 = 830.5 nM 6.08
CHEMBL1986081 — IC50 = 838.62 nM 6.08
CHEMBL1524128 — IC50 = 851.53 nM 6.07
CHEMBL1374241 — IC50 = 856.34 nM 6.07
CHEMBL1701224 — IC50 = 886.38 nM 6.05
CHEMBL1565212 — IC50 = 893.76 nM 6.05
CHEMBL1607313 — IC50 = 918.96 nM 6.04
CHEMBL1509707 — IC50 = 902.31 nM 6.04
CHEMBL1351018 — IC50 = 932.48 nM 6.03
CHEMBL1567402 — IC50 = 935.42 nM 6.03
CHEMBL1407756 — IC50 = 946.37 nM 6.02
CHEMBL1427775 — IC50 = 995.67 nM 6.00
CHEMBL1334633 — IC50 = 997.39 nM 6.00
CHEMBL1387491 — IC50 = 1062.33 nM 5.97
CHEMBL2000167 — IC50 = 1101.18 nM 5.96
CHEMBL1372447 — IC50 = 1099.67 nM 5.96
CHEMBL1373095 — IC50 = 1085.1 nM 5.96
CHEMBL1485126 — IC50 = 1093.22 nM 5.96
CHEMBL1469318 — IC50 = 1090.13 nM 5.96
CHEMBL1412105 — IC50 = 1112.95 nM 5.95
CHEMBL1532453 — IC50 = 1116.67 nM 5.95
CHEMBL1443791 — IC50 = 1133.6 nM 5.95
CHEMBL1495977 — IC50 = 1112.15 nM 5.95
CHEMBL1595221 — IC50 = 1158.53 nM 5.94
CHEMBL3213819 — IC50 = 1145.29 nM 5.94
CHEMBL1373994 — IC50 = 1143.95 nM 5.94
CHEMBL1975746 — IC50 = 1150.76 nM 5.94
CHEMBL3214598 — IC50 = 1169.1 nM 5.93
CHEMBL1362566 — IC50 = 1169.4 nM 5.93
CHEMBL1987928 — IC50 = 1174.7 nM 5.93
CHEMBL1309432 — IC50 = 1181.92 nM 5.93
CHEMBL1410616 — IC50 = 1181.59 nM 5.93