Assay Detail
Binding
CHEMBL1633799
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Inhibition of Shigella sonnei UIH-1 beta-lactamase CTX-M-64 by spectrophotometry in presence of 100 uM nitrocefin
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Shigella sonnei |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.00 | 8.00 |
| Ki | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | 8.00 |
| CHEMBL44354 | CEFTAZIDIME | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL777 | CLAVULANIC ACID | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL44354 | CEFTAZIDIME | Ki | > | 10000000.0 | nM | - |