Assay Detail
Binding
CHEMBL1634307
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Inhibition of human HDAC9 by fluorimetric assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Non-natural macrocyclic inhibitors of histone deacetylases: design, synthesis, and activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.70 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356066 | DACINOSTAT | 2.0 | 1 | 8.08 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.42 |
| CHEMBL1631914 | — | — | 1 | 7.22 |
| CHEMBL1631913 | — | — | 1 | 7.00 |
| CHEMBL1631917 | — | — | 1 | 6.91 |
| CHEMBL251011 | — | — | 1 | 6.61 |
| CHEMBL1631915 | — | — | 1 | 6.52 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.50 |
| CHEMBL1631918 | — | — | 1 | 6.49 |
| CHEMBL1631916 | — | — | 1 | 6.47 |
| CHEMBL1631911 | — | — | 1 | 6.16 |
| CHEMBL1631912 | — | — | 1 | 5.98 |
| CHEMBL1631910 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356066 | DACINOSTAT | IC50 | = | 8.24 | nM | 8.08 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 38.12 | nM | 7.42 |
| CHEMBL1631914 | — | IC50 | = | 60.6 | nM | 7.22 |
| CHEMBL1631913 | — | IC50 | = | 99.6 | nM | 7.00 |
| CHEMBL1631917 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL251011 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL1631915 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL1631918 | — | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL1631916 | — | IC50 | = | 336.0 | nM | 6.47 |
| CHEMBL1631911 | — | IC50 | = | 687.0 | nM | 6.16 |
| CHEMBL1631912 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL1631910 | — | IC50 | = | 1900.0 | nM | 5.72 |