Assay Detail
Binding
CHEMBL1634340
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]AMPA from AMPA receptor in rat brain membrane
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.47 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72366 | — | — | 1 | 6.66 |
| CHEMBL154535 | — | — | 1 | 6.43 |
| CHEMBL2092841 | — | — | 1 | 6.33 |
| CHEMBL30285 | IBOTENIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72366 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL154535 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2092841 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL30285 | IBOTENIC ACID | IC50 | > | 100000.0 | nM | - |