Assay Detail
Binding
CHEMBL1634409
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Inhibition of Influenza A virus (A/Shiga/5/2002(H3N2)) neuraminidase after 30 mins by fluorescence analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.17 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229 | OSELTAMIVIR | 4.0 | 1 | 9.15 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.32 |
| CHEMBL466246 | LANINAMIVIR | 2.0 | 1 | 8.00 |
| CHEMBL467058 | LANINAMIVIR OCTANOATE | 4.0 | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229 | OSELTAMIVIR | IC50 | = | 0.706 | nM | 9.15 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 4.82 | nM | 8.32 |
| CHEMBL466246 | LANINAMIVIR | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL467058 | LANINAMIVIR OCTANOATE | IC50 | = | 64.2 | nM | 7.19 |