Assay Detail
Functional
CHEMBL1635925
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Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum C6harboring 7G8 pfcrt allele infected in erythrocytes assessed as [3H]hypoxanthine incorporation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Role of known molecular markers of resistance in the antimalarial potency of piperaquine and dihydroartemisinin in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.20 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 9.52 |
| CHEMBL303933 | PIPERAQUINE | 3.0 | 1 | 8.18 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL303933 | PIPERAQUINE | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 126.9 | nM | 6.90 |