Assay Detail
Binding
CHEMBL1635955
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Inhibition of MMP8 by fluorimetric assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-based approach to nanomolar, water soluble matrix metalloproteinases inhibitors (MMPIs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.82 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1233772 | — | — | 1 | 8.34 |
| CHEMBL1632638 | — | — | 1 | 8.10 |
| CHEMBL311932 | — | — | 1 | 8.05 |
| CHEMBL1632639 | — | — | 1 | 8.05 |
| CHEMBL1232074 | — | — | 1 | 8.04 |
| CHEMBL1632640 | — | — | 1 | 8.00 |
| CHEMBL1234724 | — | — | 1 | 7.89 |
| CHEMBL1632637 | — | — | 1 | 7.62 |
| CHEMBL1632642 | — | — | 1 | 7.32 |
| CHEMBL1632641 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1233772 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL1632638 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL311932 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL1632639 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL1232074 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL1632640 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1234724 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL1632637 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL1632642 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL1632641 | — | Ki | = | 173.0 | nM | 6.76 |