Assay Detail
Binding
CHEMBL1635957
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Inhibition of MMP13 by fluorimetric assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-based approach to nanomolar, water soluble matrix metalloproteinases inhibitors (MMPIs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.44 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1234724 | — | — | 1 | 9.00 |
| CHEMBL1232074 | — | — | 1 | 8.77 |
| CHEMBL1632638 | — | — | 1 | 8.77 |
| CHEMBL1632639 | — | — | 1 | 8.66 |
| CHEMBL1233772 | — | — | 1 | 8.57 |
| CHEMBL1632640 | — | — | 1 | 8.54 |
| CHEMBL311932 | — | — | 1 | 8.51 |
| CHEMBL1632637 | — | — | 1 | 8.44 |
| CHEMBL1632642 | — | — | 1 | 7.75 |
| CHEMBL1632641 | — | — | 1 | 7.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1234724 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1232074 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL1632638 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL1632639 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL1233772 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL1632640 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL311932 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL1632637 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL1632642 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL1632641 | — | Ki | = | 46.0 | nM | 7.34 |