Assay Detail
Functional
CHEMBL1637305
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Antiviral activity against at 0.3 MOI Dengue virus 2 infected in human A549 cells assessed as level of E protein after 48 hrs by ELISA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | dengue virus type 2 |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.93 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1631768 | — | — | 1 | 6.38 |
| CHEMBL1630221 | — | — | 1 | 6.16 |
| CHEMBL73809 | — | — | 1 | 5.95 |
| CHEMBL1631698 | — | — | 1 | 5.85 |
| CHEMBL1630219 | — | — | 1 | 5.70 |
| CHEMBL1631769 | — | — | 1 | 5.51 |
| CHEMBL311635 | — | — | 1 | - |
| CHEMBL1631697 | — | — | 1 | - |
| CHEMBL1631699 | — | — | 1 | - |
| CHEMBL98778 | 2'-ETHYNYL-D-CYTIDINE | — | 1 | - |
| CHEMBL1631700 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1631768 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1630221 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL73809 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL1631698 | — | EC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL1630219 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1631769 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL311635 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1631697 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1631699 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL98778 | 2'-ETHYNYL-D-CYTIDINE | EC50 | > | 100000.0 | nM | - |
| CHEMBL1631700 | — | EC50 | > | 100000.0 | nM | - |