Assay Detail
Functional
CHEMBL1637565
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against Plasmodium falciparum infected in mouse RAW264.7 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.58 | 9.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL468935 | — | — | 1 | 9.23 |
| CHEMBL1629732 | — | — | 1 | 9.09 |
| CHEMBL1631347 | — | — | 1 | 9.05 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL468935 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL1629732 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL1631347 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 110.0 | nM | 6.96 |