Assay Detail
Binding
CHEMBL1637941
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Inhibition of Klebsiella pneumoniae HP205 cephalosporinase CMY-36 by UV spectrophotometer in presence of 100 uM of cephalothin
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Klebsiella pneumoniae |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Class C beta-lactamase CMY-36 (CHEMBL1641338) ↗| Type | SINGLE PROTEIN |
| Organism | Klebsiella pneumoniae |
Publication
CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.71 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL891 | CLOXACILLIN | 4.0 | 1 | 8.40 |
| CHEMBL158 | AZTREONAM | 4.0 | 1 | 8.22 |
| CHEMBL333078 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL891 | CLOXACILLIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL158 | AZTREONAM | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL333078 | — | IC50 | = | 300.0 | nM | 6.52 |