Assay Detail
Functional
CHEMBL1638142
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by standard growth inhibition assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel inhibitor of Plasmodium histone deacetylase that cures P. berghei-infected mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.73 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL468935 | — | — | 1 | 8.90 |
| CHEMBL511212 | — | — | 1 | 7.82 |
| CHEMBL1630844 | — | — | 1 | 7.52 |
| CHEMBL512644 | — | — | 1 | 6.89 |
| CHEMBL389687 | — | — | 1 | 6.66 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.05 |
| CHEMBL1630846 | — | — | 1 | 5.01 |
| CHEMBL1630845 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL468935 | — | IC50 | = | 1.25 | nM | 8.90 |
| CHEMBL511212 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1630844 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL512644 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL389687 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1630846 | — | IC50 | = | 9750.0 | nM | 5.01 |
| CHEMBL1630845 | — | IC50 | = | 10950.0 | nM | 4.96 |