Assay Detail
Functional
CHEMBL1638145
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCB1 assessed as parasite growth inhibition after 48 hrs by standard growth inhibition assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel inhibitor of Plasmodium histone deacetylase that cures P. berghei-infected mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.98 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL468935 | — | — | 1 | 9.22 |
| CHEMBL511212 | — | — | 1 | 8.22 |
| CHEMBL1630844 | — | — | 1 | 7.82 |
| CHEMBL512644 | — | — | 1 | 7.10 |
| CHEMBL389687 | — | — | 1 | 7.02 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.09 |
| CHEMBL1630845 | — | — | 1 | 5.18 |
| CHEMBL1630846 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL468935 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL511212 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1630844 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL512644 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL389687 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL1630845 | — | IC50 | = | 6550.0 | nM | 5.18 |
| CHEMBL1630846 | — | IC50 | = | 6780.0 | nM | 5.17 |