Assay Detail
Binding
CHEMBL1638258
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and α1-adrenoceptor antagonist activity of tamsulosin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.95 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL836 | TAMSULOSIN | 4.0 | 1 | 10.00 |
| CHEMBL1630938 | — | — | 1 | 9.61 |
| CHEMBL1630939 | — | — | 1 | 9.49 |
| CHEMBL1630940 | — | — | 1 | 9.02 |
| CHEMBL1630942 | — | — | 1 | 7.81 |
| CHEMBL1630941 | — | — | 1 | 7.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL836 | TAMSULOSIN | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL1630938 | — | Ki | = | 0.2455 | nM | 9.61 |
| CHEMBL1630939 | — | Ki | = | 0.3236 | nM | 9.49 |
| CHEMBL1630940 | — | Ki | = | 0.955 | nM | 9.02 |
| CHEMBL1630942 | — | Ki | = | 15.49 | nM | 7.81 |
| CHEMBL1630941 | — | Ki | = | 17.38 | nM | 7.76 |