Assay Detail
Binding
CHEMBL1638259
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Selectivity ratio of Ki for human alpha1A adrenoceptor to Ki for human Alpha-1B adrenoceptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and α1-adrenoceptor antagonist activity of tamsulosin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.00 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1630940 | — | — | 1 | 9.00 |
| CHEMBL1630939 | — | — | 1 | 6.00 |
| CHEMBL1630938 | — | — | 1 | 5.00 |
| CHEMBL1630941 | — | — | 1 | 4.00 |
| CHEMBL1630942 | — | — | 1 | - |
| CHEMBL836 | TAMSULOSIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1630940 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1630939 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1630938 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL1630941 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL1630942 | — | Ki | = | 1000000.0 | nM | - |
| CHEMBL836 | TAMSULOSIN | Ki | = | 0.0001 | nM | - |