Assay Detail
Binding
CHEMBL1638616
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human alpha5beta3gamma2 GABA receptor expressed in Xenopus laevis oocytes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
GABA-A receptor; alpha-5/beta-3/gamma-2 (CHEMBL2094122) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Developing dual functional allosteric modulators of GABA(A) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.97 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17468 | — | — | 1 | 8.52 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 7.35 |
| CHEMBL1631466 | — | — | 1 | 6.69 |
| CHEMBL1631467 | — | — | 1 | 6.34 |
| CHEMBL1631468 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17468 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL12 | DIAZEPAM | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1631466 | — | EC50 | = | 206.0 | nM | 6.69 |
| CHEMBL1631467 | — | EC50 | = | 455.0 | nM | 6.34 |
| CHEMBL1631468 | — | EC50 | = | 1130.0 | nM | 5.95 |