Assay Detail
Functional
CHEMBL1638745
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Antiviral activity against Hepatitis C virus genotype 1a in luciferase encoding genotype 1a replicons after 3 days by luciferase reporter assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel hepatitis C virus reporter replicon cell lines enable efficient antiviral screening against genotype 1a.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.79 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 7.77 |
| CHEMBL1092581 | NESBUVIR | 2.0 | 1 | 7.35 |
| CHEMBL73809 | — | — | 1 | 6.13 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297884 | CILUPREVIR | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1092581 | NESBUVIR | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL73809 | — | EC50 | = | 733.0 | nM | 6.13 |
| CHEMBL231813 | TELAPREVIR | EC50 | = | 1246.0 | nM | 5.90 |