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Assay Detail

CHEMBL1639399

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Binding
Inhibition of human placental aromatase
ChEMBL ↗
62
Total Activities
32
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Aromatase (CHEMBL1978) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Molecular docking and QSAR study on steroidal compounds as aromatase inhibitors.
Dai Y, Wang Q, Zhang X, Jia S, Zheng H, Feng D, Yu P.
Eur J Med Chem (2010) 45 : 5612 -5620
PubMed 20926163 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 32 6.03 7.51
pIC50 30 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1630274 — — 2 7.51
CHEMBL132530 FORMESTANE 2.0 2 7.38
CHEMBL1629805 — — 2 7.31
CHEMBL1630261 — — 2 7.30
CHEMBL1629802 — — 2 6.84
CHEMBL1629806 — — 2 6.72
CHEMBL1629800 — — 2 6.65
CHEMBL1630268 — — 2 6.55
CHEMBL1630263 — — 2 6.19
CHEMBL1630910 — — 1 6.18
CHEMBL1630264 — — 2 6.18
CHEMBL1630280 — — 2 6.17
CHEMBL1630269 — — 2 6.16
CHEMBL1630272 — — 2 6.07
CHEMBL1630267 — — 2 6.03
CHEMBL1630266 — — 2 6.00
CHEMBL1630270 — — 2 6.00
CHEMBL1630260 — — 2 5.82
CHEMBL1630262 — — 2 5.75
CHEMBL1630276 — — 2 5.75
CHEMBL1630909 — — 2 5.73
CHEMBL1630279 — — 2 5.62
CHEMBL1630265 — — 2 5.44
CHEMBL1630277 — — 2 5.35
CHEMBL1630278 — — 2 5.26
CHEMBL1629803 — — 2 5.19
CHEMBL1630273 — — 2 5.17
CHEMBL1630911 — — 1 5.16
CHEMBL1630271 — — 2 4.96
CHEMBL1629801 — — 2 4.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1630274 — IC50 = 31.0 nM 7.51
CHEMBL132530 FORMESTANE IC50 = 42.0 nM 7.38
CHEMBL1629805 — IC50 = 49.0 nM 7.31
CHEMBL1630261 — IC50 = 50.0 nM 7.30
CHEMBL1629802 — IC50 = 145.0 nM 6.84
CHEMBL1629806 — IC50 = 190.0 nM 6.72
CHEMBL1629800 — IC50 = 225.0 nM 6.65
CHEMBL1630268 — IC50 = 280.0 nM 6.55
CHEMBL1630263 — IC50 = 640.0 nM 6.19
CHEMBL1630910 — IC50 = 660.0 nM 6.18
CHEMBL1630264 — IC50 = 660.0 nM 6.18
CHEMBL1630280 — IC50 = 670.0 nM 6.17
CHEMBL1630269 — IC50 = 700.0 nM 6.16
CHEMBL1630272 — IC50 = 860.0 nM 6.07
CHEMBL1630267 — IC50 = 940.0 nM 6.03
CHEMBL1630266 — IC50 = 1000.0 nM 6.00
CHEMBL1630270 — IC50 = 1000.0 nM 6.00
CHEMBL1630260 — IC50 = 1500.0 nM 5.82
CHEMBL1630262 — IC50 = 1800.0 nM 5.75
CHEMBL1630276 — IC50 = 1800.0 nM 5.75
CHEMBL1630909 — IC50 = 1850.0 nM 5.73
CHEMBL1630279 — IC50 = 2400.0 nM 5.62
CHEMBL1630265 — IC50 = 3600.0 nM 5.44
CHEMBL1630277 — IC50 = 4500.0 nM 5.35
CHEMBL1630278 — IC50 = 5500.0 nM 5.26
CHEMBL1629803 — IC50 = 6500.0 nM 5.19
CHEMBL1630273 — IC50 = 6800.0 nM 5.17
CHEMBL1630911 — IC50 = 6900.0 nM 5.16
CHEMBL1630271 — IC50 = 11000.0 nM 4.96
CHEMBL1629801 — IC50 = 30000.0 nM 4.52
CHEMBL1630265 — pIC50 = -0.556 uM -
CHEMBL1630266 — pIC50 = -0.146 uM -
CHEMBL1630267 — pIC50 = 0.027 uM -
CHEMBL1629800 — pIC50 = 0.648 uM -
CHEMBL1630269 — pIC50 = 0.155 uM -
CHEMBL1630270 — pIC50 = - uM -
CHEMBL1630271 — pIC50 = -1.041 uM -
CHEMBL1630272 — pIC50 = 0.066 uM -
CHEMBL1630273 — pIC50 = -0.833 uM -
CHEMBL1630274 — pIC50 = 1.509 uM -
CHEMBL1630275 — pIC50 = -2.176 uM -
CHEMBL1630276 — pIC50 = -0.255 uM -
CHEMBL1630277 — pIC50 = -0.653 uM -
CHEMBL1630278 — pIC50 = -0.74 uM -
CHEMBL1630279 — pIC50 = -0.38 uM -
CHEMBL1630280 — pIC50 = 0.174 uM -
CHEMBL1630909 — pIC50 = -0.267 uM -
CHEMBL1630275 — IC50 = 150000.0 nM -
CHEMBL1629804 — IC50 = 60.0 nM -
CHEMBL1630268 — pIC50 = 0.553 uM -