Assay Detail
Binding
CHEMBL1639409
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-alpha-Bungarotoxin from alpha7 nAChR rat cortical membranes by gamma counting
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.18 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1630288 | — | — | 1 | 6.36 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 6.33 |
| CHEMBL274525 | ABT-418 | — | 1 | 5.92 |
| CHEMBL1630294 | — | — | 1 | 5.54 |
| CHEMBL1630293 | — | — | 1 | 4.95 |
| CHEMBL1630290 | — | — | 1 | 4.46 |
| CHEMBL1630287 | — | — | 1 | 4.40 |
| CHEMBL1630291 | — | — | 1 | 4.37 |
| CHEMBL186295 | — | — | 1 | 4.31 |
| CHEMBL1630289 | — | — | 1 | - |
| CHEMBL1630292 | — | — | 1 | - |
| CHEMBL1630295 | — | — | 1 | - |
| CHEMBL185124 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1630288 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL3 | NICOTINE | Ki | = | 469.0 | nM | 6.33 |
| CHEMBL274525 | ABT-418 | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL1630294 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL1630293 | — | Ki | = | 11300.0 | nM | 4.95 |
| CHEMBL1630290 | — | Ki | = | 35000.0 | nM | 4.46 |
| CHEMBL1630287 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL1630291 | — | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL186295 | — | Ki | = | 49000.0 | nM | 4.31 |
| CHEMBL1630289 | — | Ki | = | 325000.0 | nM | - |
| CHEMBL1630292 | — | Ki | = | 277000.0 | nM | - |
| CHEMBL1630295 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL185124 | — | Ki | > | 50000.0 | nM | - |