Assay Detail

CHEMBL1639844

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of Hepatitis C virus genotype 1a JFH-1 recombinant NS5B polymerase after 30 mins by phosphor imaging

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Hepatitis C virus subtype 1a
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.

Lam AM, Murakami E, Espiritu C, Steuer HM, Niu C, Keilman M, Bao H, Zennou V, Bourne N, Julander JG, Morrey JD, Smee DF, Frick DN, Heck JA, Wang P, Nagarathnam D, Ross BS, Sofia MJ, Otto MJ, Furman PA.
Antimicrob Agents Chemother (2010) 54 : 3187 -3196
PubMed 20516278 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.55	5.55

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL486231	GS-461203	-1.0	1	5.55

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL486231	GS-461203	IC50	=	2800.0	nM	5.55