Assay Detail

CHEMBL1640082

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ADMET

Inhibition of monkey aldehyde oxidase

ChEMBL ↗

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Target

Aldehyde oxidase 1 (CHEMBL1641357) ↗

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Aldehyde oxidase 1 (CHEMBL1641357) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Aldehyde oxidase 1

CHEMBL1641357

Anchored from Assay target.

Protein identity Aldehyde oxidase 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Macaca fascicularis
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Aldehyde oxidase 1 (CHEMBL1641357) ↗

Type	SINGLE PROTEIN
Organism	Macaca fascicularis

Publication

Aldehyde oxidase: an enzyme of emerging importance in drug discovery.

Pryde DC, Dalvie D, Hu Q, Jones P, Obach RS, Tran TD.
J Med Chem (2010) 53 : 8441 -8460
PubMed 20853847 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	4	5.91	6.96

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL590	MENADIONE	4.0	1	6.96
CHEMBL81	RALOXIFENE	4.0	1	6.30
CHEMBL567	PERPHENAZINE	4.0	1	5.44
CHEMBL135	ESTRADIOL	4.0	1	4.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL590	MENADIONE	IC50	=	110.0	nM	6.96
CHEMBL81	RALOXIFENE	IC50	=	500.0	nM	6.30
CHEMBL567	PERPHENAZINE	IC50	=	3600.0	nM	5.44
CHEMBL135	ESTRADIOL	IC50	=	12000.0	nM	4.92