Assay Detail
Binding
CHEMBL1645659
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.46 | 4.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643773 | — | — | 1 | 4.46 |
| CHEMBL561132 | MK-7246 | 1.0 | 1 | - |
| CHEMBL1643783 | — | — | 1 | - |
| CHEMBL1643789 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643773 | — | Ki | = | 35000.0 | nM | 4.46 |
| CHEMBL561132 | MK-7246 | Ki | > | 39000.0 | nM | - |
| CHEMBL1643783 | — | Ki | > | 60000.0 | nM | - |
| CHEMBL1643789 | — | Ki | > | 60000.0 | nM | - |